Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6. In vitro studies have suggested these mutations affect several signaling pathways. but in vivo studies have largely compared wild-type and Trpc6-deficient rodents. https://www.bekindtopets.com/super-pick-Rx-Quadruple-Topical-Ointment-Quadritrop-for-Dogs-Cats-30-mL-super-grab/