Background: Altered balance between striatal direct and indirect pathways contributes to early motor. cognitive and psychiatric symptoms in Huntington disease (HD). While degeneration of striatal D2-type dopamine receptor (D2)-expressing indirect pathway medium spiny neurons (iMSNs) occurs prior to that of D1-type dopamine receptor (D1)-expressing direct pathway neurons. altered corti... https://www.roneverhart.com/Happy-Camper-Dog-Shirt/