We consider cancer cytotoxic drugs as an optimal control problem to stabilize a heterogeneous tumor by attacking not the most abundant cancer cells. but those that are crucial in the tumor ecosystem. We propose a mathematical cancer stem cell model that translates the hierarchy and heterogeneity of cancer cell types by including highly structured tumorigenic cancer stem cells that yie... https://www.roneverhart.com/Corvette-Door-Handle-Accent-Leather-2005-2013-C6-Z06-ZR1-Grand-Sport/