Mutation in TP53 is a common genetic alteration in human cancers. Certain tumor associated p53 missense mutants acquire gain-of-function (GOF) properties and confer oncogenic phenotypes including enhanced chemoresistance. The colorectal cancers (CRC) harboring mutant p53 are generally aggressive in nature and difficult to treat. https://www.lightemupsequences.com/limited-value-Icicles-No-6-Textured-Glass-Dildo-8-5in-Clear-Pink-mega-pick/