Background: Angelman syndrome (AS) is a genetic neurodevelopmental disorder caused by the loss of function of the UBE3A protein in the brain. In a previous study. we showed that activity-dependent calcium dynamics in hippocampal CA1 pyramidal neurons of AS mice is compromised. and its normalization rescues the hippocampal-dependent deficits. https://fitnessgravesyardes.shop/product-category/phone-board-wire/